3 edition of Mechanisms and control of emesis found in the catalog.
Mechanisms and control of emesis
|Other titles||Mécanismes et contrôle du vomissement., Nouvelles données sur les mécanismes et le contrôle du vomissement.|
|Statement||edited by Armand L. Bianchi ... [et al.].|
|Series||Colloque INSERM -- vol. 223, Colloques de l"Institut national de la santé et de la recherche médicale -- vol. 223.|
|Contributions||Bianchi, Armand L., European Neuroscience Association.|
|LC Classifications||RC809 .M42 1992|
|The Physical Object|
|Pagination||xxii, 371 p. :|
|Number of Pages||371|
|ISBN 10||2855985110, 0861963660|
Rudd JA and Naylor RJ: Effects of 5-hydroxytryptamine-3 receptor antagonists on models of acute and delayed emesis induced by cisplatin in the ferret. To make sure ondansetron is safe for you, tell your doctor if you have: liver disease; an electrolyte imbalance such as low levels of potassium or magnesium in your blood ; congestive heart failure, slow heartbeats; a personal or family history of long QT syndrome; or a blockage in your digestive tract stomach or intestines. Vomiting occurs when the vomiting centres present in the lateral reticular formation of the medulla are stimulated. Altered blood bears resemblance to coffee grounds as the iron in the blood is oxidized and, when this matter is identified, the term coffee-ground vomiting is used.
The mechanism of action exerted by gabapentin is unknown. This system has a rich supply of muscarinic receptors. Monges H, Salducci J, Naudy B: Dissociation between the electrical activity of the diaphragmatic dome and crura muscular fibres during oesophageal distention, vomiting and eructation. Forty-eight ferrets Mustela putorius furo were individually head-shielded and radiated with bilateral cobalt 60 gamma radiation at cGy min at doses ranging between 49 and cGy.
It is more challenging to control and treat than acute or delayed CINV. Tell your doctor if you are breast-feeding a baby. Antiperistaltic waves push the gut contents into duodenum, stomach and partially into the esophagus. Once the pressure within the stomach is sufficiently high, the lower esophageal sphincter LES opens completely and the vomitus is expelled out into the mouth.
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Under normal circumstances the gag reflex and coughing prevent this from occurring; however, these protective reflexes are compromised in persons under the influence of certain substances including alcohol or are even mildly anesthetized.
This helps to expel the last remnants of the vomitus from the oesophagus. The CNS: When the higher brain centres such as the cerebrum are affected by stress or certain psychiatric conditions, this can also result in vomiting.
Harris AL: Cytotoxic therapy induced vomiting is mediated via enkephalin pathways. Rate this:. Other areas of the brain can also stimulate the vomiting center, either directly or indirectly.
Bile can enter the vomit during subsequent heaves due to duodenal contraction if the vomiting is severe. A historical perspective In the early s, treatment for CINV included the corticosteroid dexamethasone.
Ondansetron is not expected to harm an unborn baby. Giorgio Bonola ca. It has a short duration of action; virtually complete in the first 24 hours after chemotherapy adminstration. Recent food intake appears in the gastric vomit. How does vomiting occur? In particular, the discovery of the 5-hydroxytryptamine 5-HT3 receptor and the development of 5-HT3 receptor antagonists RAs ondansetron, granisetron, tropisetron, dolasetron, palonosetron significantly advanced the treatment of CINV.
About these proceedings Introduction The following papers were presented at an international symposium on the mechanisms and treatment of nausea and vomiting in man held in Oxford in By comparison, the mouse 0.
These results were consistent with the previous phase II and phase III studies using olanzapine and suggest that olanzapine is an effective and safe agent for the control of both emesis and nausea Table This further stimulates the vomiting center. Tell your doctor if you have phenylketonuria PKU.
To make sure ondansetron is safe for you, tell your doctor if you have: liver disease; an electrolyte imbalance such as low levels of potassium or magnesium in your blood ; congestive heart failure, slow heartbeats; a personal or family history of long QT syndrome; or a blockage in your digestive tract stomach or intestines.
Do not take this medicine in larger or smaller amounts or for longer than recommended. The tested PrC doses were the ferret and rat equivalent doses of the 0. Picture by Giovanni Dall'Orto, December 6 The human equivalent of this mouse 0.
An attempt was made to put before an invited international audience all the pertinent facts on the different facets of the topic and then to encourage extensive discussion of the contentious issues. The effect of CINV on patients' quality of life can be devastating, and patients who experience uncontrollable nausea and vomiting associated with their therapy may be reluctant to continue with additional chemotherapy.
This is attributed to the adverse memory of previous CINV. Do not push a tablet through the foil or you may damage the tablet. It continues for 60—96 hours after the administration of HEC.Matsuki N, Torii Y, Ueno S, Saito H: Suncus murinus as an experimental animal model for emesis and motion sickness.
In: Bianchi AL, Grelot L, Miller AD, King GL eds Mechanisms and Control of Emesis. Colloque INSERM, J Libbey, Eurotext – Google ScholarCited by: 3.
TABLE 1. Effects of Surgical Lesions on Radiation-induced Emesis Average Average No. of Emesis after latency Average duration Lesion dogs irradiation (min) episodes (rain) None 5 5 96 Area postrema ablation 2 0 -- -- -- Subdiaphragmatic vagotomy 2 2 4 Mechanisms of radiation-induced emesis in the dog TABLE sylvaindez.com by: 4.
There have been considerable advances in the understanding of the mechanisms of chemotherapy- and radio-therapy-induced emesis over the past 10 years which has been translated into the clinic with the introduction of the selective 5-HT3 receptor antagonists of which ondansetron was the Format: Taschenbuch.
Control of CINV. The main approach to the control of emesis has been to identify the active neurotransmitters (Figure ) and their receptors in the CNS and the GI tract that mediate the afferent inputs to the VC.
The receptors associated with serotonin and substance P are 5-hydroxytryptamine-3 (5-HT3) and neurokinin-1 (NK-1), respectively. Learn emesis with free interactive flashcards. Choose from different sets of emesis flashcards on Quizlet.
To identify the mechanisms inherent in incision-induced postoperative pain, a specific surgery-related animal model in rats was developed in the 90s of the last century.
19, By using this plantar incision model (and other animal models developed thereafter investigating specific aspects of pain after surgical trauma), we have learnt much.